[14] In 1853, the French chemist Alexandre Lallemand named thymol and determined its empirical formula. The dose ranges from 3 to 15 grains. [18] Thymol demonstrates in vitro post-antibacterial effect against the test strains E. coli and P. aeruginosa (gram negative), and Staphylococcus aureus and B. cereus (gram positive). [14] In 1853, the French chemist Alexandre Lallemand named thymol and determined its empirical formula. Mix thoroughly, and divide into 20 pills. [21], The antifungal nature of thymol against some fungi that are pathogenic to plants is due to its ability to alter the hyphal morphology and cause hyphal aggregates, resulting in reduced hyphal diameters and lyses of the hyphal wall. Then weigh 59g of thymol crystals, and pour them carefully into the empty bottle. Analgesic properties are also possessed by it. The Blackfoot Native Americans recognized these plants' strong antiseptic action, and used poultices of the plants for skin infections and minor wounds. [21], The antifungal nature of thymol against some fungi that are pathogenic to plants is due to its ability to alter the hyphal morphology and cause hyphal aggregates, resulting in reduced hyphal diameters and lyses of the hyphal wall. Dr. B. Kussner has found that from 3 to 5 drops of a 1 per cent solution of thymol is beneficial in diarrhoea of children. [27], In 2009, the U.S. Environmental Protection Agency (EPA) reviewed the research literature on the toxicology and environmental impact of thymol and concluded that "thymol has minimal potential toxicity and poses minimal risk".[41]. The preferable forms, for the internal administration of thymol are either to dissolve it in an alcoholic drink, or to form it into a thick, emulsioned fluid; but, thus far, the employment of this agent has been confined chiefly to its use as a topical application, and to utilize its antiseptic properties. Thymol ≥98.5% Synonym: 2-Isopropyl-5-methylphenol, 5-Methyl-2-(1-methylethyl) phenol, 5-Methyl-2-isopropylphenol, IPMP CAS Number 89-83-8. Thymol, a component of the botanical thyme oil, when used as a disinfectant active ingredient on Seventh Generation disinfection products, kills 99.99% of household germs. Jour. Soluble in about 1200 parts of water at 15° C. (59° F.), and in less than its own weight of alcohol, ether, or chloroform; also readily soluble in carbon disulphide, glacial acetic acid, and in fixed or volatile oils. The nervous phenomena were represented by tinnitus aurium, deafness, and a sense of constriction at the temples (Archiv der Heilkunde, Vol. [11] In this period, women also often gave knights and warriors gifts that included thyme leaves, as it was believed to bring courage to the bearer. of thymol be heated in a test-tube, in a water-bath, with 5 Cc. [20], Thyme essential oil is useful in preservation of food. Animals poisoned with it pass into a deep coma; after death their blood is dark and fluid, but no fatty degeneration of internal organs is observed (Med. Thymol has been used in alcohol solutions and in dusting powders for the treatment of tinea or ringworm infections, and was used in the United States to treat hookworm infections. Blackie Academic Professional; London, UK: 1995. pp. Gould G.W., editor. It is also soluble in strongly alkaline aqueous solutions due to deprotonation of the phenol. Beilstein/REAXYS Number 1907135 . Thymol (also known as 2-isopropyl-5-methylphenol, IPMP) is a natural monoterpenoid phenol derivative of p-Cymene, C10H14O, isomeric with carvacrol, found in oil of thyme, and extracted from Thymus vulgaris (common thyme), Ajwain[3] and various other kinds of plants as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties. [10] In the European Middle Ages, the herb was placed beneath pillows to aid sleep and ward off nightmares. Each of CleanWell's thymol cleaning products contains a 0.05% concentration of thymol and is designed to kill 99.9% of germs, bacteria, and viruses. M. Baelz, who has made some comparative experiments with thymol and salicylic acid (in the service of M. Wunderlich) upon persons in health, and also those affected with typhoid fever, articular rheumatism, phthisis, and pyelitis, states that in doses of ⅙ of a grain, repeated several times, no effect was observed; in order to obtain an appreciable therapeutical result, it was necessary to give daily from 25 to 30 grains. It should be kept in well-stoppered bottles"—(U. S. P.). Manley. Prof. Webster reports a satisfactory use of thymol in expelling tapeworm. Description.—Thymol, as described by the U. S. P., forms "large, colorless, translucent crystals of the hexagonal system, having an aromatic, thyme-like odor, and a pungent, aromatic taste, with a very slight caustic effect upon the lips. King's American Dispensatory, 1898, was written by Harvey Wickes Felter, M.D., and John Uri Lloyd, Phr. D. Henriette's herbal is one of the oldest and largest herbal medicine sites on the net. Listerine is an agreeable non-irritant and non-escharotic antiseptic preparation composed of the essential antiseptic constituents of thyme, eucalyptus, gaultheria, baptisia, and Mentha arvensis combined with refined benzo-boracic acid. It is very extensively employed in the antiseptic treatment of operative and accidental wounds, and as a general cleansing agent in medical and dental practice. Related Preparation.—LISTERINE. It is a remedy for chyluria. Listerine is a transparent amber-colored fluid becoming cloudy or opaque below 60° F., but clearing again as the temperature reaches that figure. Tests. Mix. In cases in which fermentation occurs in the stomach with dilatation of this organ, he states that thymol acts promptly in arresting the accompanying vomitings, and gradually effects a contraction of this dilated cavity. FORMULA: C10H14O. [25] Thymol is also used as a rapidly degrading, non-persisting pesticide. [9] The ancient Greeks used it in their baths and burnt it as incense in their temples, believing it was a source of courage. [10] In the European Middle Ages, the herb was placed beneath pillows to aid sleep and ward off nightmares. The antibacterial properties of thymol, a major part of thyme essential oil, as well as other constituents, are in part associated with their lipophilic character, leading to accumulation in bacterial membranes and subsequent membrane-associated events, such as energy depletion. Being a phenol, thymol readily dissolves in caustic alkalies and is regenerated by acids, even carbonic acid (see Preparation, above). When employed in the dressing of ulcers, etc., the following solution has been recommended by M. Giraldes: Take of thymol, from ½ to 1 drachm; alcohol, 3 fluid ounces; distilled water, 30 fluid ounces. [citation needed] It is also used as a preservative in halothane, an anaesthetic, and as an antiseptic in mouthwash. The spread of thyme throughout Europe was thought to be due to the Romans, as they used it to purify their rooms and to "give an aromatic flavour to cheese and liqueurs". The advantages derived from its internal administration have been very limited. [24] Thymol is also the active antiseptic ingredient in some toothpastes, such as Johnson & Johnson's Euthymol. 58–59. Thymol blue | C27H30O5S | CID 65565 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. A solution of perchloride of iron added to the urine rendered it cloudy, and of a whitish-gray color. Upon coming in contact with the bucco-pharyngeal mucous membrane, the medicine occasioned a pricking sensation and a disagreeable taste; there was seldom any nausea, and vomiting occurred but once among 36 persons. Linear Formula 2-[(CH 3) 2 CH]C 6 H 3-5-(CH 3)OH . Ten drops of the solution will suffice for inhalation during 4 or 5 days. Ten drops of a thick, concentrated solution of thymol are placed in a small glass flask, furnished with a cork, through which pass two bent glass tubes, one descending nearly to the bottom of the flask, the other being short. Source, History, and Preparation.—Thymol was discovered by Caspar Neumann in 1719. Formula: C₂₇H₃₀O₅S MW: 466.6 g/mol Storage Temperature: Ambient: MDL Number: MFCD00005869 CAS Number: 76-61-9 EINECS: 200-973-3 UN: 1170 ADR: 3,II: Order Now. Ord.—Labiatae), and Carum Ajowan (Roxburgh), Bentham et Hooker (Nat.

Fifteen grains of thymol dissolved in 2 pints of distilled water, forms an invaluable disinfectant; this has been found effective in disinfecting sick rooms, and as a local application to prevent septicemia during the parturient period, as well as at other times when there is reason to fear its development.

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